A Washington Post-ABC News poll showed a 12% point lead for the Democrat, her largest advantage since last fall and a dramatic improvement over last month when the poll showed her statistically tied with Trump.
If the presidential election were held today, 51% of respondents said they would vote for Clinton, versus 39% for Trump.
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They were essentially tied, 39% for Clinton and 38% for Republican opponent, when third-party candidates were included, this poll showed.
The surveys come after a difficult month for the combative Trump, a political novice who fired his campaign manager and faced criticism for poor campaign organisation and a paltry war chest of $1.3 million at the end of May.
Clinton, who has repeatedly pounded Trump as being "temperamentally unfit," finished the month with $42 million.
Trump faced a widespread outcry after he accused a federal judge of bias because of his Mexican heritage. The judge is presiding over cases involving Trump's defunct online university.
And in the aftermath of the mass shooting at a gay nightclub in Orlando, the brash businessman tweeted his thanks to people who congratulated him for "being right on radical Islamic terrorism."
He renewed calls for a temporary ban on Muslims entering the US and then doubled down, suggesting profiling of Muslims was not off the table.
On Saturday, Trump seemed to change course, saying immigration from "regions linked with terrorism" should be suspended.
"I think there's no question that he's made a number of mistakes over the last few weeks," Republican Mitch McConnell, the Senate majority leader, told ABC News on Sunday.
"I think they're beginning to right the ship. It's a long time until November. And the burden, obviously, will be on him to convince people that he can handle this job."
According to the Washington Post-ABC News poll, two in three Americans say Trump is unqualified to lead the nation, are anxious about the idea of a Trump presidency and find his comments about women, minorities and Muslims to show an "unfair bias."
However, survey respondents also indicated unease with former secretary of state Clinton.
A majority disprove of the way Clinton has handled questions over her use of a personal email server during her tenure as the nation's top diplomat, and half are anxious about the idea of her in the White House.
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