The 31-year-old Duchess of Cambridge gave birth to a baby boy last evening at 16:24 (local time) at the private Lindo wing at St Mary's Hospital in Paddington, central London.
The fountain in Trafalgar Square was lit up with blue lighting to mark the birth of the third in line to Britain's throne and "It's a boy" was instantly being flashed on the BT Tower in central London.
Queen Elizabeth II is expected to have been the first to be informed about her newest great-grandson by phone.
Prince Charles, the grandfather of the 8lbs 6oz boy, responded to news of the birth by saying he was "enormously proud and happy" of becoming a grandparent.
"Both my wife and I are overjoyed at the arrival of my first grandchild. It is an incredibly special moment for William and Catherine and we are so thrilled for them on the birth of their baby boy," he said.
British Prime Minister David Cameron was among the first to take to Twitter to say: "I'm delighted for the Duke and Duchess now their son has been born. The whole country will celebrate. They'll make wonderful parents".
The statement issued by Kensington Palace, the Duke and Duchess' official residence, confirmed that William was present for the birth.
US President Barack Obama and lawmakers congratulated the royal family on the birth of the new prince.
"Michelle and I are so pleased to congratulate The Duke and Duchess of Cambridge on the joyous occasion of the birth of their first child. We wish them all the happiness and blessings parenthood brings," he said.
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