Trump has spent weeks cajoling, strong-arming and warning Republicans to get on board with his effort to overhaul his successor's health care reforms, but several are skeptical about how the new plan could affect millions of Americans.
In recent weeks, several measures have been considered -- but ultimately collapsed, revealing fissures within the Republican Party on how to proceed with a goal they have had since the Affordable Care Act was passed in 2010.
The latest Republican plan would dismantle Obamacare but delay the actual implementation of the repeal to allow time for a viable replacement to be crafted.
That bill is highly unlikely to pass in its current form, but the Senate leadership has stressed the importance of at least voting on it in order for changes to then be introduced.
"This will be a very interesting day for HealthCare," Trump tweeted. "The Dems are obstructionists but the Republicans can have a great victory for the people!"
Ahead of the vote, the path forward remained murky, irritating some Republicans.
"I don't have a clue what we'll be voting on," Senator Ron Johnson, a Republican who has long criticized the health care reform process, said Monday.
Ideologically conservative Senator Ted Cruz said it remained "unclear exactly which legislative solutions will carry the day."
But he encouraged a vote to begin debate.
"Now is the time to prove that our rhetoric of the past seven years regarding the repeal and replacement of this disastrous bill will lead to substantive action," Cruz said in a statement.
He and other Senate Republican leaders acknowledge they do not know whether there is sufficient support to even open debate on the new plan, a sign of Republican division about the impact such reforms might have on millions of American families.
On the Democratic side, senators urged cooperation -- and restraint.
"I can't believe this process and the hard and calculated rhetoric we see," Democratic Senator Joe Manchin of West Virginia said Tuesday.
"The Affordable Care Act is not a perfect piece of legislation. It needs repair. We both agree to that. Then we need to fix it."
"Any senator that votes against starting debate is telling America that you are fine with the Obamacare nightmare," Trump said.
Trump has repeatedly grilled fellow Republicans for not following through on their -- and his -- campaign pledge to repeal and replace Obamacare.
Republicans hold 52 of the Senate's 100 seats. With all Democrats opposed, Trump can afford just two defectors.
Senator John McCain, who was convalescing in Arizona following a brain cancer diagnosis, returned to Washington today, in yet another sign of how important the numbers are for this vote.
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