State television said in a breaking news alert that there had been dead and wounded in the "terrorist explosion" in the Tadamun neighbourhood, without immediately giving any further details.
The Syrian Observatory for Human Rights said a car bomb had killed at least seven people and wounded 15, some of them critically.
Tadamun is largely controlled by rebels fighting to overthrow President Bashar al-Assad.
But the blast took part in part of the neighbourhood that is still under the control of the Syrian army.
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