The warning comes in the wake of increasing terrorist violence, including sectarian attacks, in Pakistan.
In a travel warning - issued after a gap of seven months - the State Department warned the US citizens against all non-essential travel to the South Asian country.
The fresh travel warning replaces earlier warning, issued on May 22.
Pakistan continues to experience significant terrorist violence, including sectarian attacks, the State Department said, adding that targeted attacks against government officials, humanitarian and non-governmental organisation (NGO) employees, tribal elders, and law enforcement personnel were common in the country.
Terrorists have targeted US diplomats and diplomatic facilities in the past, and evidence suggests they continue to do so, the travel warning said, adding that terrorists and criminal groups have resorted to kidnapping for ransom.
Sectarian violence, the State Department said, remains a serious threat throughout the country, and the Pakistani government continues to enforce blasphemy laws.
Religious minority communities have been victims of targeted killings and accusations of blasphemy, it added.
The State Department said insurgent and terrorist groups conducted numerous suicide bombings, hand grenade attacks, and ambushes on Pakistani security forces and civilians over the past six months in Balochistan.
Two hand grenade attacks in Gwadar and Mastung injured 41 people. In Quetta, a suicide bomber killed 21 people and wounded 45 in an attack on the Pishin bus terminal, the State Department said.
Similarly, a suicide bomber in Jhal Magsi attacked worshippers at the Sufi shrine of Pir Rakhyal Shah in the Fatehpur area, killing 19 and injuring 30. Another suicide bomber in Quetta attacked a police convoy on the Sibbi Road in the Saryab mill area, killing seven and wounding 23, it said.
In Khyber-Pakhtunkhwa province and the Federally Administered Tribal areas (FATA), there have been numerous recent attacks by insurgent and terrorist groups targeting government officials, NGO and aid workers, religious minorities, and civilians. Also 148 occurrences of small arms fire, over 67 improvised explosive devices (IED) explosions, 28 known assassination attempts, and 17 kidnappings were reported, the State Department said.
Assassination and kidnapping attempts are common throughout these areas, it added.
The Department said terrorist organisations operating in the area have not discriminated between government officials and civilians.
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