A total of 23 positive results came from 265 retested samples, the International Olympic Committee said, on top of over 30 previous failed tests from competitors who had been caught either during the Games or since.
The high percentage of apparent doping offences sparked suggestions on Friday that London was rife with cheating, but Coe denies that is the case.
Coe, now the president of world athletics' governing body the IAAF, served as the London 2012 organising committee chairman.
The IOC has said its reanalysis programme is ongoing, with the possibility of more results in the weeks to come.
Coe wrote in his newspaper column: "It would be delusional to say the London Games was 'in the words of many yesterday' dirtier than Games before."
"We will not stop collecting data, sharing information, building profiles, developing testing techniques or calling out and prosecuting cheats in our efforts to protect and promote clean sport. The Rio 2016 Games will be cleaner for it. That should be the story."
Russia has said eight of its athletes are among the 23 to have tested positive on reanalysis.
All athletes found to have infringed the anti-doping rules will be banned from competing at the Rio Olympics this summer.
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