Another meek performance in losing for the fifth time this season in midweek to Juventus has put Jose Mourinho's position as Manchester United manager back in peril ahead of in-form Everton's visit to Old Trafford on Sunday.
On a run of just one win in seven games in all competitions, United already look out of the title race, nine points adrift of Manchester City and Liverpool, but are also in danger of missing out on the top four with Chelsea, Arsenal and Tottenham also just two points off the top.
There is the chance for United to make up some ground as Tottenham host City on Monday, but Liverpool, Chelsea and Arsenal will be confident of maintaining their strong starts to the season against struggling Cardiff, Burnley and Crystal Palace respectively.
Here, AFP Sport looks at what to watch out for in the Premier League this weekend:
Little home comfort
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Guardiola's glory days at Wembley
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Benitez's last stand?
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Fixtures (all times GMT)
Saturday
Southampton v Newcastle, Watford v Huddersfield, Brighton v Wolves, Fulham v Bournemouth, Liverpool v Cardiff (1400), Leicester v West Ham (1630) Sunday Burnley v Chelsea, Crystal Palace v Arsenal (1230), Manchester United v Everton (1500)
Monday
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