Sources said that the explosion took place inside the Mar Gerges Coptic Church in Tanta.
At least 15 people were injured, media reports said.
No official statement has been released.
The explosion comes as Egyptian Christians celebrate the Palm Sunday today.
Egypt's Christian minority has often been targeted by Islamist militants. Egypt has seen a wave of attacks by militants since 2013 when the military overthrew President Mohammed Morsi, an elected leader who hailed from the Muslim Brotherhood, and launched a crackdown against Islamists.
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