The economy was expected to grow between 2.0 and 2.3 percent this year, instead of the 2.3-2.6 percent range seen three months ago, the Fed said.
For 2014, gross domestic product growth was trimmed to 2.9-3.1 percent, from the June estimate of 3.0-3.5 percent.
The central bank's unemployment outlook improved slightly for this year and the next.
The 2013 jobless rate was estimated between 7.1 percent and 7.3 percent, the Fed said, while in 2014 it would fall to 6.4-6.8 percent.
Tame inflation forecasts continued to remain well below the Fed's 2.0 percent target for price stability.
The 2013 estimate for core inflation, stripping out food and energy price changes, was unchanged at 1.2-1.3 percent. The rate was not expected to climb as high as 2.0 percent until 2015.
For the first time, the Fed provided forecasts for 2016. GDP growth would slow to 2.5-3.3 percent, while the unemployment rate would fall to 5.4-5.9 percent.
Inflation in 2016 was projected at 1.90-2.0 percent.
According to the updated forecasts, most Fed policy makers see the first hike in the federal funds rate in 2015.
The policy makers said they would keep it in this exceptionally low range, where it has been since late 2008, as long as the unemployment rate remains above 6.5 percent and inflation does not threaten.
The first time the jobless rate was projected to come in below that threshold is in 2015, when the Fed estimates the rate will fall to 6.2 percent or lower.
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