The hospital building, made of wood, was destroyed by the fire, the ministry said.
A further 20 people were hospitalised.
The hospital building, made of wood, was destroyed by the fire, the ministry said.
The fire broke out shortly before midnight (2100 GMT) Saturday at the hospital in the village of Alferovka, which is located in the region of Voronezh in the south of the country.
It took more than 440 firefighters and emergency workers, who arrived at the scene aboard around 80 vehicles, around three hours to bring the fire under control.
The fire was the latest tragedy to hit a psychiatric institution in Russia, where outdated Soviet-era infrastructure is still in widespread use and managers often take a lax approach to fire safety.
Scores of people also die in house fires each year.
A fire at a psychiatric hospital in northwest Russia in September 2013 left 37 people dead, while another blaze in April of the same year killed 38.
In 2009, 156 people were killed in a nightclub fire in the city of Perm, 1,200 kilometres (700 miles) east of Moscow in one of the deadliest accidents in Russia's modern history.
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