Steffen Seibert says it will be the first time the Cabinet's specially created 'Brexit' committee holds a formal meeting.
It takes place a day after UK Prime Minister Theresa May gives a much-anticipated speech with details of Britain's goals in exit negotiations with the EU.
Other members of the Cabinet committee include Economy Minister Sigmar Gabriel, Finance Minister Wolfgang Schaeuble and Merkel's chief of staff, Peter Altmaier.
Seibert told reporters in Berlin today that "German interests need to be identified in order to bring them to the negotiations."
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