The suspect's motive wasn't immediately clear, but the city of Macerata is still reeling from the gruesome killing of a young Italian woman this week, allegedly at the hands of a Nigerian immigrant.
Police said all those wounded were foreigners and they later confirmed the arrest of the unidentified suspect about two hours after the shooting erupted in the city of Macerata.
Video posted by the newspaper il Resto di Carlino showed what appeared to be a body on the ground on a shopping street.
The head of the anti-migrant Northern League, Matteo Salvini, has capitalized on the killing in campaign appearances, and is pledging to deport 150,000 migrants in his first year in office if his party wins control of parliament and he is named premier.
The teen's dismembered remains were found Wednesday in two suitcases, two days after she walked away from a drug rehab community.
Police haven't said how many people have been wounded in today's shootings.
Police had warned people to stay inside while the shootings were ongoing. Authorities ordered public transport halted and that students be kept inside schools, which are open on Saturdays.
Italians vote in the general election on March 4.
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