Two men opened fire last night on the family, from Afghanistan's Hazara community, who were at a bus station in Quetta preparing to travel to the southern city of Karachi.
"A man of about 65 years of age and his 18-year-old grandson were killed in the firing at the bus terminal at Sariyab road," Imran Qureshi, a senior police official, told AFP.
Two other men and two women family members managed to run away and take shelter. The gunmen escaped on a motorbike.
A man describing himself as a member of the banned Sunni Muslim extremist group Jaish-ul-Islam called media outlets to claim responsibility for the attack.
Quetta is the capital of Baluchistan province, which is torn both by a separatist insurgency and violence directed against Shiites.
They make up around 20 per cent of Pakistan's population, which is largely Sunni Muslim.
According to a report by a Human Rights Watch, more than 400 Shiites were killed in targeted attacks across the country in 2013.
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