Clooney turned 56 yesterday.
"Happy Birthday George! Feliz Cumpleanos Jorge! #georgeclooney," she captioned her photo with Clooney, which also shows actor Will Smith in the frame with all three actors dressed in white.
Hayek and Clooney have co-starred in three films together "From Dusk till Dawn", "Full Tilt Boogie" and "Spy Kids 3-D: Game Over".
Actress Cindy Crawford also wished the "Ocean's 11" star on his birthday.
"Happy birthday to one of the classiest guys we know!" Crawford accompanied her photo with Clooney and husband Rande Gerber on Instagram.
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