The legislation was approved 407-5, underscoring the broad support it has attracted to combat a problem that claims victims across racial, economic and geographic lines.
"Let's come together and get the job done. What we're doing will save lives," said Rep Fred Upton, R-Mich, chairman of the House Energy and Commerce Committee.
Unlike many bills in this highly partisan Congress, the House-Senate compromise was written by members of both parties, and early versions of the measure were approved overwhelmingly by both chambers.
After a morning of floor speeches in which members of both parties called for a period of healing, House Minority Leader Nancy Pelosi, D-Calif, said that "in the spirit of this day," Democrats should back the legislation and seek the extra money later.
With the House's lopsided vote, Senate Democratic aides said the measure was now on track to win final congressional approval from the Senate and was expected to be signed by President Barack Obama.
More than 47,000 people die yearly from drug overdoses, a death rate that has more than doubled since 2000. Around 6 in 10 of those fatalities were caused by heroin and opioids, potentially addictive medications that are prescribed to kill pain. The government has estimated that more than 2 million Americans have opioid abuse problems, plus nearly 500,000 more who are heroin addicts.
Recovery services for addicts would be expanded, states could get financial incentives for providing a full range of opioid abuse services, and more medical workers would be allowed to prescribe buprenorphine, which can wean people off opioids.
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