The 45-year-old singer, who already has three sons with her husband Rene Angelil, said she had to undergo in-vitro fertilisation to help her conceive her sons, reported Contactmusic.
"There's nothing that can top being a mother. I would like more but I don't know if it could happen. I want the twins and me to have quality time," Dion said.
"It's selfish to keep wanting more, although I would love a girl. Imagine all the shopping, the jewellery, the shoes, the dresses I could give to her," she added.