Khamenei, who has the last say in matters of policy, also said he believes Iran's parliament (majlis) should make up its own mind about landmark July 14 deal struck with six world powers.
"I believe... That it is not in the interest of the majlis to be sidelined," Khamenei said.
"I have no recommendation for the majlis on how it should examine it; it is up to the representatives of the nation to decide whether to reject or ratify it".
Most US lawmakers oppose it, but President Barack Obama has enough backers in the Senate to uphold his certain veto of any congressional resolution disapproving it.
The majlis announced in mid-August the makeup of a 15-member panel largely composed of conservative lawmakers to review the historic deal.
But the government and the deal's negotiators believe a parliamentary vote is not in the best interest of Iran, arguing that it would transform a voluntary promise made by Tehran into a legal obligation.
But formal oversight of the accord rests with Iran's Supreme National Security Council, a powerful committee headed by President Hassan Rouhani, which reports to Khamenei.
Khamenei, who has said in past weeks that the fate of the nuclear deal remains unclear, insisted today that if decades of "sanctions are not lifted, then there will be no deal."
He noted that some "American officials speak very badly" of the agreement, without identifying anyone by name.
Yesterday, US Secretary of State John Kerry said Iran will be required to live up to the agreement in full before its starts benefitting from sanctions relief.
The deal between Iran and Britain, China, France, Germany, Russia and the United States aims to curb Tehran's nuclear drive in exchange for a gradual lifting of sanctions imposed on its economy since 2006.
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