Ayatollah Ali Khamenei, who has final say on all state matters, urged his countrymen to boost economic, scientific and military capabilities through increased efforts at home, saying the country will follow the "correct" path in negotiations.
"Powers should know that Iranian nation will not bow," under pressures, state television quoted Khamenei as saying.
The next round of high-level negotiations between Tehran and six world powers assembles tonight but official talks begin tomorrow to reach a final agreement to limit Iran's ability to produce nuclear weapons before a July 20 deadline.
On Sunday, Iran's moderate President said his country would not surrender what it considers its right to nuclear development, but that it would be "transparent" in negotiations over the contested program.
The West has long been concerned Tehran's real aim is to produce an atomic weapon.
Iran denies the charge and insists its nuclear program is peaceful, aimed at producing electricity and medical treatment.
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