"We are always optimistic. But we have a difficult road to go," Abbas Araqchi told reporters after a day of talks in Vienna with officials from France, Germany and Britain.
He added after "useful" discussions that the differences between the two sides remain "big" as they attempt to nail down what would be an historic accord before November 24.
Britain, France and Germany form part of a six-nation group with the United States, Russia and China due to resume negotiations with Iran in New York on September 18.
The recent diplomatic flurry also saw Iranian Foreign Minister Mohammad Javad Zarif fly to Moscow, Brussels and Paris as well as Rome to meet Federica Mogherini, the incoming EU foreign policy chief from November 1.
The P5+1 powers, all of which except Germany sit on the UN Security Council and have nuclear weapons themselves, want Iran to scale back its atomic programme to ease fears the Islamic republic gets the bomb.
Tehran, which says its nuclear programme is exclusively for electricity generation and medical uses, in return wants painful UN and Western sanctions lifted.
The main problem issue remains the size of Iran's capacity to enrich uranium, a process that can make fuel for peaceful nuclear uses but also the core of an atomic bomb.
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