The attack may have targeted the pro-Iran Afghan Voice news agency housed in the two-story building. The Sunni extremists of IS view Shiite Muslims as apostates and have repeatedly attacked Afghanistan's Shiite minority and targets linked to neighboring Iran.
The attack wounded more than 80 people, many of whom suffered severe burns.
Local Shiite leader Abdul Hussain Ramazandada said the bomber slipped into an academic seminar at the center and blew himself up among the participants. More bombs went off just outside the center as people fled.
Ali Reza Ahmadi, a journalist with Afghan Voice, said he leaped from the window of his second-floor office after the first bomb went off and saw flames pouring from the basement.
"I jumped from the roof toward the basement, yelling at people to get water to put out the fire," he said.
At nearby Istiqlal Hospital, Director Mohammed Sabir Nasib said the emergency room was overwhelmed. Additional doctors and nurses were called in to help. At the height of the crisis, more than 50 medics were working to save the wounded.
The cultural center was housed in a simple building surrounded by mud-brick homes in the Shiite-dominated neighborhood of Dasht-e-Barchi, home to some of Kabul's poorest residents.
A senior member of the local Shiite clerical council, Mohammad Asif Mesbah, said the center may have been targeted because it houses Afghan Voice. The news agency's owner, Sayed Eissa Hussaini Mazari, is a strong proponent of Iran, and the agency's output is dominated by Iranian news.
Today, the center was marking the anniversary of the 1979 Soviet invasion with a seminar about the event's impact on the country.
Iran, a Shiite-majority country bordering Iraq and Afghanistan, has provided heavy military and financial aid to the Syrian government as well as regional Shiite militias battling IS in recent years.
The extremist group is now largely confined to a few remote patches of territory in Syria, but it retains the ability to inspire and carry out attacks further afield.
Powerful affiliates in Afghanistan and Egypt's Sinai Peninsula continue to launch regular assaults against security forces and civilians.
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