The train from Milan, Italy, to Basel derailed shortly before 2 pm as it was pulling out of Lucerne's main train station, Swiss railway company SBB said.
The Trenitalia train's fourth carriage tipped over and a power line was interrupted. There were 160 passengers aboard at the time.
Lucerne police said the passengers were evacuated and three people were given treatment. SBB said that train service to and from the station was suspended at least for the rest of the day.
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