Two months after a quake left nearly 300 dead in the country's tremor-prone central spine, two powerful shocks ripped through the mountainous, sparsely-populated region yesterday evening.
Despite numerous building collapses, no deaths had been reported by midday, more than 17 hours after the first of the 5.5 and 6.1 magnitude tremors.
"Given the strength of the shocks the absence of any deaths or serious injuries, which we hope will be confirmed, is miraculous," Interior Minister Angelino Alfano said.
Rescue workers began a major clean-up operation and hundreds of families were unsure where they would be living for the forseeable future.
More than 100 aftershocks rattled the area through the night after the initial two were felt in Rome, some 175km (110 miles) away from the epicentres.
Marco Rinaldi, mayor of the village of Ussita, described "apocalyptic" scenes. "People were in the streets screaming. Many houses have collapsed. Our town is finished," he said.
"I've felt a lot of earthquakes but that was the strongest I've ever felt. Fortunately everyone had already left their homes after the first quake so I don't think anyone was hurt."
Even in Rome, some people took to the streets as a precautionary measure, underlining lingering jitters after the summer disaster.
Wednesday's tremors struck an area just to the north of Amatrice, the mountain town which was partially razed by the August quake and suffered the bulk of the fatalities.
The epicentres were near the village of Visso, located on the edge of the region of Marche close to the border with Umbria.
Across the region, hospitals, a university residence, a retirement home and even a prison had to be evacuated.
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