In a battle of two unseeded players, the 21-year-old Indian, ranked 645, was no match for her 18-year-old 393-ranked opponent and went down 3-6 3-6 to make her exit.
Kamila was on top throughout the 75-minute encounter against the Indian girl, breaking Prerna's serve five times.
The Indian woman played a much better second set, but still lost the match to a superior and higher ranked opponent.
The other semifinal will see top seed Linette Magda clashing with third seed Diana Marcinkevica of Latvia.
The loss of Sowjanya Bavisetti-Sharmada Balu in the doubles semi-finals later in the afternoon meant that the Indian challenge is over in this tournament.
The results:
Singles (Quarter finals): Linette Magda (POL) [1] bt Rika Fujiwara (JPN) 6-3 5-7 6-2; Diana Marcinkevica (LAT) [3] bt Nungnadda Wannasuk (THA) 6-3 7-5; Gioia Barbieri (ITA) [4] bt Keren Schlomo (ISR)6-2 6-3; Kamila Kerimbayeva (KAZ) bt Prerna Bhambri (IND)6-3 6-3.
Doubles (Semi finals): Nicha Lertpitaksinchai/Peangtarn Plipuech (THAI) [2] bt Ksenia Palkina (KGZ)/Jade Windley (GBR) [3] 6-2, 6-3; Jocelyn Rae/Anna Smith (GBR) bt Sharmada Balu /Sowjanya Bavisetti (IND) 6-1, 7-6(7).
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