The 35-year-old 'This is the End' star plays a struggling actor called James in multimedia artist Carter's feature film debut, reported Digital Spy.
The movie centres around a family all marked by their own mental illnesses.
They struggle to find a place of happiness in a world that does not understand them.
Catherine Keener, Alan Cumming and Fallon Goodson also feature in the film.
Franco will also be seen in the upcoming films 'Good People', 'Every Thing Will Be Fine' and 'Black Dog, Red Dog'.
'Maladies' will arrive in cinemas in March.
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