Lawyer-turned-politician Tomomi Inada, 57, becomes the second woman to oversee the defence ministry after Yuriko Koike, who served briefly in 2007. Koike was elected governor of Tokyo on Sunday.
Inada, a four-term lawmaker, was formerly policy chief of Abe's ruling Liberal Democratic Party and shares his hawkish views on Japan's 20th century history.
Inada, who replaces Gen Nakatani, was named to the post as part of a partial revamp by Abe of his cabinet after the LDP's big win in upper house parliamentary elections last month.
Inada, a mother of two children, has a history of irritating Asian neighbours such as China and South Korea.
She has been a regular visitor to Tokyo's contentious Yasukuni war shrine and has played a leading role in an LDP study group launched last year to review Japan's history, reportedly taking up contentious issues such as the Nanjing massacre and the Tokyo war crimes trials.
They flew to a Seoul airport to push Tokyo's claim to the disputed islands and refused to fly back home for hours after their entry to South Korea was denied.
Japan is also embroiled in long-running territorial disputes with China and Russia.
In the cabinet revamp announced by Chief Cabinet Secretary Yoshihide Suga, Abe left most key posts untouched, with Fumio Kishida, the foreign minister, and Taro Aso, finance minister and deputy prime minister, keeping their posts.
Besides Inada, other new picks include Hiroshige Seko for economy, trade and industry minister and previous environment minister Tamayo Marukawa as the minister in charge of the 2020 Tokyo Olympics.
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