Civil Aviation spokesman Hector Olivo says the twin-engine Hawker Siddeley was flying from Santo Domingo to Punto Cana on the eastern tip of the country but never arrived at its destination.
Olivo said authorities were searching for the plane today and were not certain how many people were on board.
The jet is registered to a company based in Dover, Delaware. It took off yesterday and the control tower lost contact shortly afterward.
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