"I am deeply concerned by the wave of anti-Semitic attacks and threats that has been sweeping across the United States in recent days and weeks," the agency's chairman Nathan Sharansky said in a statement.
"I trust that US authorities will act resolutely to find those responsible, bring them to justice, and prevent such incidents from recurring," Sharansky wrote.
In his maiden speech to Congress yesterday, President Donald Trump spoke out against anti-Semitic incidents and also condemned the seemingly racially-motivated killing of an Indian man in a Kansas bar.
Sharansky, whose semi-governmental agency is the world's largest Jewish non-profit organisation, argued there was no distinction between the far-right's demonisation of Jews and the radical left's demonisation of the Jewish state of Israel.
"These two ugly phenomena feed on one another and both run counter to the foundations of democratic societies in Europe and America," he said.
The Anti-Defamation League has offered a USD 10,000 reward for information leading to the arrest and conviction of those responsible.
The incident came a week after more than 100 headstones were damaged at a Jewish cemetery in St Louis, Missouri.
It prompted a Muslim-led crowdfunding campaign to raise more than USD 100,000 to repair the cemetery, and a visit by Vice President Mike Pence.
Vandals spray-painted swastikas on several cars, highway overpasses, buildings and an elementary school playground over the weekend in Buffalo, New York, The Buffalo News reported.
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