Seeking his fourth Atlanta title in five seasons, the big-serving Isner will face third-seeded Gilles Muller of Luxembourg. Muller beat American Tommy Paul 6-3 6-1.
Isner won the Hall of Fame Open on Sunday in Newport, Rhode Island, for his 11th career title - all at the ATP World Tour 250 level. The 6-foot-10 former University of Georgia star lost to Nick Kyrgios last year in the final at Atlantic Station after winning the hard-court event the previous three seasons.
Fourth-seeded Ryan Harrison also advanced, beating Christopher Eubanks 6-1, 6-2 in an all-American match. Top- seeded Jack Sock of the United States faced fifth-seeded Kyle Edmund of England in the night match.
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