Clooney, who is politically active and leans towards the Democratic Party, has often been touted as a future candidate for the post of the USA president.
But the 56-year-old actor says she believes the position should only be assumed by someone who is "experienced in government", reported You magazine.
"Honestly, I can't bear it, this idea of relating leaders with entertainment figures.
"What you want is a president who is experienced in government. You don't want a reality show person. I don't even want to joke about movie stars being president of the United States," Moore said when asked about Clooney.
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