Kerry, who had earlier postponed his visit, will hold meetings with President Asif Ali Zardari, Prime Minister Nawaz Sharif and army chief General Ashfaq Kayani tomorrow.
This is Kerry's maiden visit to Pakistan after becoming the Secretary of State.
Bilateral relations and regional situation especially resumption of strategic dialogue between Pakistan and the United States besides the issue of drone strikes will be discussed during Kerry's meeting with the top leadership.
Pakistan and US will hold discussion on regional situation with particular reference to post 2014 situation in Afghanistan, Associated Press of Pakistan reported.
In Washington, State Department spokesperson Jen Psaki said, Kerry will have "consultations with the newly-elected civilian government and to reinforce the United States' continuing commitment to the Pakistani people."
"Kerry's discussions will focus on a wide range of topics including promoting security, strengthening the Pakistani economy, and reinforcing people-to-people ties between the United States and Pakistan, in addition to regional topics of mutual interest," Psaki said in a statement.
Aziz said issues relating to drone attacks in Pakistan's tribal areas and the situation in Afghanistan would also come up for discussions.
The US is looking to Pakistan to play a key role in the withdrawal of its troops from Afghanistan in 2014 but the two sides have been unable to reach common ground on involving the Afghan Taliban in peace negotiations.
Pakistani-US ties were strained after the killing of al-Qaeda chief Osama bin Laden at his hideout in Pakistan's Abbottabad town on May 2, 2011.
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