"We're pushing some tough issues, but we made progress," Kerry told reporters in the Swiss city of Lausanne during a break from talks involving Iranian Foreign Minister Mohammad Javad Zarif that are lasting all week.
"We are advancing very well but there's still a lot of work to be done," Zarif told Iran's state news agency IRNA.
A European diplomat involved in the negotiations said that Iran and six major powers -- the US, China, Russia, Britain, France and Germany -- remained "pretty far" from a deal.
He also said that he did not expect a breakthrough by Friday, the tentative scheduled end of the talks, meaning that negotiators will likely have to return next week.
That chimed with Iran's foreign minister who said on Wednesday that the arrival of other foreign ministers -- which might suggest a deal is at hand -- was not expected this week.
"When the solutions are found and we approach a deal, then all the foreign ministers of the negotiating parties should come," Zarif told state media from Lausanne.
Iran's nuclear chief Ali Akbar Salehi, also present along with US Energy Secretary Ernest Moniz, said however late Wednesday that this was still not certain.
"We don't know yet, we still have two days to go," he told reporters.
The mooted agreement, due to be finalised by July, is aimed at convincing the world after a standoff now in its 13th year that Iran won't build nuclear weapons under the guise of its civilian programme.
The highly complex deal would likely involve Iran reducing in scope its nuclear activities, allowing ultra-tight inspections, exporting abroad nuclear material and halting development of new nuclear machinery.
But Tehran, which denies wanting nuclear weapons, wants to expand its activities in order to fuel nuclear power stations and meet its energy needs.
On Tuesday the White House said the chances of such a deal are 50/50 "at best" with "some of the most difficult issues... yet to be resolved."
Negotiators missed two deadlines last July and November to clinch a deal despite numerous rounds of talks around the world.
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