The study, by Australia's Flinders University Professor Mike Nicholls and colleagues, set out to test the theory that left-handed children are smarter, naughtier and more prone to illness and injury than right-handed children.
Scientists, including researchers from Monash University and the University of California, analysed data from the US National Longitudinal Survey of Youth to measure physical health, mental health and cognitive development across four key areas - vocabulary, mathematics, reading and comprehension.
However, he said left-handed children achieved significantly lower cognitive development scores for all areas except reading.
"It's often claimed that left-handers are more likely to have health problems such as asthma but we didn't find any different outcomes between left and right-handers," Nicholls said.
"Some evidence suggests that left-handers are also more accident-prone but our results show that isn't the case - if left-handers do experience injury it's probably not due to clumsiness but rather the struggle of interacting in a right-handed world," he said.
Nicholls said the data showed a distinct subset of left-handers with lower cognitive abilities, suggesting that perhaps some left-handers acquire developmental problems at birth and may benefit from extra tutoring.
"Based on our findings it's likely that left-handed children will need a bit of extra help with schooling to get them up to a higher level but it could also be a matter of making their work environment better so they're not constantly bumping arms with the kid next to them or using right-handed scissors," Nicholls said.
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