Light-activated drug to help treat diabetes

Scientists have developed a new drug for type 2 diabetes that is switched on by blue light, which can improve treatment of the disease and reduce side effects of diabetes medication.
Diabetes drugs that promote the release of insulin from the pancreas can in some cases cause side effects due to their actions on other organs such as the brain and heart. Some can also stimulate too much insulin release, causing blood sugar levels to drop too low, researchers said.
To help create better drugs, researchers at Imperial College London and Ludwig Maximilian University of Munich adapted an existing type of drug called a sulfonylurea so that it changes shape when exposed to blue light.

The drug would be inactive under normal conditions, but a patient could in theory switch it on using blue LEDs stuck to the skin.
Only a small amount of light would need to penetrate the skin to change the drug's shape and turn it on. This change is reversible, so the drug switches off again when the light goes off.
The researchers demonstrated that the prototype drug, known as JB253, stimulates insulin release from pancreatic cells in the lab when exposed to blue light.

"In principle, this type of therapy may allow better control over blood sugar levels because it can be switched on for a short time when required after a meal. It should also reduce complications by targeting drug activity to where it's needed in the pancreas," said Dr David Hodson from the Department of Medicine at Imperial, who led the study.

"So far, we've created a molecule that has the desired effect on human pancreatic cells in the lab. There's a long way to go before a therapy is available to patients, but this remains our ultimate goal," said Hodson.
Type 2 diabetes impairs people's control over their blood sugar levels, leading to higher risk of heart disease and stroke and potentially causing damage to the kidneys, nerves and retinas.
Although molecules that react to light have been known about since the 19th century, only in the last few years have scientists exploited their properties to make light-sensitive molecules with drug effects.

"Photoswitchable drugs and photopharmacology could be enormously useful for all sorts of diseases, by allowing remote control over specific body processes with light," said Professor Dirk Trauner from LMU Munich, who also led the study.
The study was published in the journal Nature Communications.