Lack of relationships is a bigger health risk for people under age 65, researchers said.
"The effect of this is comparable to obesity, something that public health takes very seriously," said Julianne Holt-Lunstad from Brigham Young University.
"We need to start taking our social relationships more seriously," said Holt-Lunstad, the lead study author.
Loneliness and social isolation can look very different. For example, someone may be surrounded by many people but still feel alone.
The association between loneliness and risk for mortality among young populations is actually greater than among older populations.
Although older people are more likely to be lonely and face a higher mortality risk, loneliness and social isolation better predict premature death among populations younger than 65 years.
"Not only are we at the highest recorded rate of living alone across the entire century, but we're at the highest recorded rates ever on the planet," said Tim Smith, co-author of the study.
The study analysed data from a variety of health studies. Altogether, the sample included more than 3 million participants from studies that included data for loneliness, social isolation, and living alone.
Controlling for variables such as socioeconomic status, age, gender, and pre-existing health conditions, they found that the effect goes both ways.
The lack of social connections presents an added risk, and the existence of relationships provides a positive health effect.
Previous research from Holt-Lunstad and Smith puts the heightened risk of mortality from loneliness in the same category as smoking 15 cigarettes a day and being an alcoholic.
"In essence, the study is saying the more positive psychology we have in our world, the better we're able to function not just emotionally but physically," Smith said.
The study appears in the journal Perspectives on Psychological Science.
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