"My team and I are in negotiations with Amir Khan for our next fight. Further announcements coming soon," Pacquiao, 38, said on his official Twitter feed.
Spokesmen for Pacquiao could not be contacted for comment.
Pacquiao's Tweet follows various accounts from different sources over who he will be facing next and where the fight might be held.
Pacquiao's promoter, Top Rank's Bob Arum, told ESPN sports network that he was sceptical about a Khan fight.
Arum had been seeking a deal with Duco Events, a New Zealand promotional company he has close ties to, for Pacquiao to defend the 147-pound belt against Australia's Jeff Horn in Brisbane, Australia.
"The Australian deal is not going to happen now, because Manny is trying to get a fight done in the United Arab Emirates, and the people there favour him fighting Amir Khan," Arum reportedly said.
Since January, Arum had been widely quoted as saying the Filipino would next face Horn in April, although Pacquiao's aides insisted nothing had been confirmed.
Pacquiao, the WBO welterweight champion, tweeted on February 11: "See you in UAE for my next fight. #TeamPacquiao".
He also posted a poll on his Twitter feed asking his 108,000 followers to choose either Horn, Khan, American Terence Crawford or Briton Kell Brook as his next opponent.
The poll has since been taken down.
Pacquiao announced a brief retirement last year but made a successful comeback against Jessie Vargas in Las Vegas in November, saying he still felt like a youngster.
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