"The toll is heavy and worrying: since January 1, 2015, more than 20,000 cases of measles have been registered in Katanga province alone" and "almost 320 people have died", the UN Office for the Coordination of Humanitarian Affairs (OCHA) said in a statement this week.
"Dozens of others may have succumbed to the illness but they don't figure on official records," the statement added.
The outbreak in mineral-rich Katanga is the worst since 2011, according to Medecins Sans Frontieres (MSF - Doctors without Borders), which is on the front line of a vaccination campaign in remote areas. In 2011, MSF staff immunised about 1.5 million children.
OCHA warned that in 2015 the situation "is only getting worse" and said that some of the affected areas also face malnutrition and cholera.
"In populations with high levels of malnutrition and a lack of adequate health care, up to 10 percent of measles cases result in death," the UN World Health Organisation (WHO) noted on its website.
Aid agencies say that about a third of the affected areas in Katanga are covered by a vaccination programme.
The United Nations and medical charities estimate that more than 2.4 million dollars (2.15 million euros) are needed to complete vaccinations and provide other essential care. But to contain the disease of "an epidemic nature", other serious obstacles must be confronted.
Though a highly contagious disease, measles can easily be countered by a vaccine, which has virtually wiped it off the map in Western countries.
"Most deaths are caused by complications associated with the disease," according to the WHO. "The most serious complications include blindness, encephalitis (an infection that causes brain swelling), severe diarrhoea and related dehydration, ear infections, or severe respiratory infections such as pneumonia.
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