"I have repeatedly said that I personally wish that Great Britain stays part of the European Union," she told a Berlin press conference.
Citing the example of international trade talks, she pointed to the benefits of being part of the EU bloc and the risks of isolation.
"One nation by itself will never be able to achieve such good results" in trade negotiations, Merkel said.
Outcomes reached as part of the 28-nation bloc "will be qualitatively better for the people of Great Britain... I'm very certain of that".
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