Now, after decades of low TB rates thanks to antibiotics and strong public health systems, the continent is threatened by a new and different form of the lung disease - one which cannot easily be cured with existing drugs.
And the people most at risk, experts say, are migrants and refugees who often find themselves in densely-populated, unsanitary, disease-favourable conditions similar to those blamed for Europe's Victorian era "Great White Plague".
"Although rare in European countries, the risks posed by the current migrant crisis makes MDR-TB (multi- drug-resistant tuberculosis) an important and urgent health priority," the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) said in a recent statement.
Infections on European soil were mainly among migrants themselves, and public health experts stress they should be viewed as a vulnerable group in need of help -- not disease spreaders.
A hundred per cent of MDR-TB cases in Austria, the Netherlands and Norway were diagnosed in migrants and refugees, said the ESCMID, and around 90 per cent in Britain, France, Italy and Germany.
This represented just over 1,400 cases in 12 countries in 2014.
Some migrants may arrive already sick with MDR-TB, others with a latent, unobserved infection.
"Migrants are among the most susceptible groups to tuberculosis," Michel Kazatchkine, the UN secretary-general's special envoy on HIV/AIDS in Eastern Europe and Central Asia, told AFP.
"Most of them acquire a disease in the host country," he said.
Drug-resistant TB strains are more difficult and expensive to treat.
Symptoms are not immediately visible, and the disease can spread easily from one person to another via coughing, sneezing, or simply talking.
But many cases may never be spotted, as European countries do not have a standardised approach to screening.
"The situation in Europe is such that governments are now tightening up in terms of who is able to access free statutory health services," Sally Hargreaves of the International Health Unit at Imperial College London, told AFP.
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