Pryor, who was hailed as one of the best stand-up comedians, died of a heart attack in December 2005. He was 65.
TV star Oprah Winfrey, who is rumoured to have been cast in the film to play Pryor's grandmother, posted a picture of herself with Epps and director Lee Daniels on Instagram.
Daniels tweeted the same photo and captioned it, "Get ready you'all- Mike Epps as Richard Pryor." Later Epps, 43, posted a picture of himself with the late funnyman's wife Jennifer Pryor.
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