The exchange halted trade in all "Tape C" securities, which includes options and securities. A message from Nasdaq around 1615 GMT recommended traders route transactions to other exchanges.
The tech-rich exchange said on it website that it intends to resume trading "at a time to be determined." The exchange said customers wishing to cancel orders could do so.
A spokesman for the Securities and Exchange Commission said the US securities regulator was monitoring the situation and was "in close contact with the exchanges."
Nasdaq attributed the shutdown to a problem with its SIP system, which interfaces with other exchanges on stock quotes.
The Nasdaq index was up 0.87 per cent at 3,631.17 when trading was halted.
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