Between October 2, the day after the contested vote, and October 19 a total of 1,185 companies have relocated hoping to minimise instability, according to figures published by the Commercial Registries of Spain.
The peak was reached yesterday as 268 companies shifted their headquarters out of Catalonia.
Spain's central government announced that day that it would start seizing some of the Catalan regional government's powers after the region's leader declared he could declare independence.
The companies that have moved their headquarters include listed firms such as CaixaBank, Spain's third largest lender, and Gas Natural as well as medium as medium-sized firms such as food group Idilia Foods.
A survey by a Catalan association for small and medium sized businesses, Pimec, found that around 1,300 companies that employ up to 250 people have decided to move they legal headquarters out of Catalonia without necessarily having started the administrative formalities.
About two percent of the companies said they had changed banks in recent weeks, without specifying if it was from a bank based in Catalonia to one elsewhere in Spain.
While there have been calls on social media in Spain for a boycott of Catalan products, such as cava sparkling wine, the head of Pimec, Josep Gonzalez, said during an interview with private television Antena 3 such campaigns "are not desirable for anyone".
Products made in Catalonia include a "significant percentage" of materials that are bought in other regions of Spain," he said.
"If we enter in a dynamic of boycott, it will hurt us all," Gonzalez said.
Spain's central government has slashed its economic growth forecast for 2018 to 2.3 per cent because of the uncertainty sparked by Catalonia's independence drive.
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