New artificial leaf may serve as 'mini-factory' for drugs

Scientists have developed a novel leaf-shaped device that can be used to produce medicines sustainably and cheaply, anywhere you want - in the middle of the jungle or even on Mars.
Inspired by the art of nature where leaves are able to collect enough sunlight to produce food, researchers at Eindhoven University of Technology in the Netherlands created prototype reactor - shaped as a leaf.
Using sunlight to make chemical products has long been a dream of many a chemical engineer. The problem is that the available sunlight generates too little energy to kick off reactions, researchers said.
However, nature is able to do this. Antenna molecules in leaves capture energy from sunlight and collect it in the reaction centres of the leaf where enough solar energy is present for the chemical reactions that give the plant its food.

The researchers came across relatively new materials, known as luminescent solar concentrators (LSC's), which are able to capture sunlight in a similar way.
Special light-sensitive molecules in these materials capture a large amount of the incoming light that they then convert into a specific colour that is conducted to the edges via light conductivity.

These LSC's are often used in practice in combination with solar cells to boost the yield.
Researchers, led by Timothy Noel, combined the idea of an LSC with their knowledge of microchannels, incorporating very thin channels in a silicon rubber LSC through which a liquid can be pumped.

In this way they were able to bring the incoming sunlight into contact with the molecules in the liquid with high enough intensity to generate chemical reactions.
While the reaction they chose serves as an initial example, the results surpassed all their expectations, and not only in the lab.
"Even an experiment on a cloudy day demonstrated that the chemical production was 40 per cent higher than in a similar experiment without LSC material," said Noel.
For the production of drugs there is certainly a lot of potential. The chemical reactions for producing drugs currently require toxic chemicals and a lot of energy in the form of fossil fuels.

By using visible light the same reactions become sustainable, cheap and, in theory, countless times faster.
"Using a reactor like this means you can make drugs anywhere, in principle, whether malaria drugs in the jungle or paracetamol on Mars. All you need is sunlight and this mini-factory," he said.
The study was published in the journal Angewandte Chemie.