New portable device for at-home kidney tests

Scientists have developed a lightweight and portable device that attaches to a smartphone and can be used to conduct at-home kidney tests and get instant results.
The gadget may significantly reduce the need for frequent hospital visits by people with diabetes and others with chronic kidney ailments, researchers said.
The device invented at University of California, Los Angeles weighs about one-third of a pound and transmits data through a smartphone attachment.
The smartphone-based device was developed in the research lab of Aydogan Ozcan, a professor of electrical engineering and bioengineering at the UCLA Henry Samueli School of Engineering and Applied Science, and associate director of the California NanoSystems Institute.

The gadget can determine levels of albumin in the patient's urine and transmit the results within seconds. Albumin is a protein in blood that is a sign of danger when found in urine.
Ozcan's lab also developed the opto-mechanical phone attachment, disposable test tubes, Android app and software to transmit the data.

"Albumin testing is frequently done to assess kidney damage, especially for diabetes patients. This device provides an extremely convenient platform for chronic patients at home or in remote locations where cell phones work," Ozcan said.
Patients at risk for diabetes, kidney disease and other ailments must regularly provide fluid samples - sometimes more than one a day - to monitor their health, which requires visits to labs or health centers.

The new device projects beams of visible light through two small fluorescent tubes attached to the device, one containing a control liquid and the other a urine sample mixed with fluorescent dyes.
The smartphone camera captures the fluorescent light after it passes through an additional lens.
An Android application then processes the raw images in less than one second and the device transmits the test results to a database or health care provider.
The test, which measures albumin concentration in urine, is accurate to within less than 10 micrograms per millilitre, according to the research, well within accepted clinical standards used in diagnosing conditions such as microalbuminuria, the excretion of albumin in urine.

The time it takes to conduct a test, including preparation of a sample using a small syringe to inject the urine into a fluorescent tube, is about five minutes.
Ozcan estimated that the device could be produced commercially for USD 50 to USD 100 per unit.
The research was published in the journal Lab on a Chip.