The accident occurred in Nooriabad area near Jamshoro district. Four of the eight injured were in critical condition, the Dawn reported
The passenger bus was travelling from Hyderabad to Karachi when it rammed into the trailer.
The injured have been shifted to a nearby hospital after police and rescue teams reached the accident site.
Meanwhile, in another road accident two people were killed when two trailers collided on a highway in Naushehro Feroz district of Sindh province.
The bodies were shifted to a nearby hospital by rescue teams.
Pakistan has one of the world's worst records for fatal traffic accidents owing to dilapidated roads, poorly maintained vehicles and reckless driving.
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