Obama's administration has faced criticism for not including the continent's most populous country on a Africa tour later this week that will take in Kenya and Ethiopia.
By hosting Muhammadu Buhari in the Oval Office, the US president hopes to underscore that the African giant, also the continent's biggest economy, is vital US interests.
Praise for Nigeria's recent elections - the first won by an opposition challenger against an incumbent - is likely to be coupled with tricky discussions on combating Boko Haram militants.
So far 15,000 people have been killed and 1.5 million displaced by the conflict.
Buhari's visit has been foreshadowed by a uptick in terror attacks, including suicide bombings in neighboring Cameroon and Chad.
Rights groups say atrocities have been committed both by Boko Haram and the Nigerian military.
US laws banning the transfer of weapons to countries suspected of rights abuses have sometimes pushed a wedge between the two allies.
Obama's administration last year blocked the sale of Cobra attack helicopters to Nigeria, hampering cooperation amid efforts to find the hundreds of still-unfound kidnapped Chibok schoolgirls.
Earlier this month Buhari sacked his entire military top brass.
Buhari's purge of senior commanders inherited from his predecessor Goodluck Jonathan was widely expected but is the clearest demonstration yet of his quest for a fresh start.
Still, Obama is unlikely to endorse a dramatic ramping up of US military activity against Boko Haram - fearing it could be used by the group as a recruiting tool and entangle the United States in yet another conflict.
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