Obese moms may put babies at risk of heart disease: study

The walls of the body's major artery - the aorta - are already thickened in babies born to mothers who are overweight or obese, according to a new study.
Australian researchers found that this arterial thickening, which is a sign of heart disease, is independent of the child's weight at birth - a known risk factor for later heart disease and stroke.
The study may explain how overweight or obese mothers may contribute to their children's subsequent risk of heart disease and stroke in later life.
Researchers pointed out that up to 60 per cent of women of child bearing age in developed countries are overweight or obese.

Twenty-three women, whose average age was 35, were included in the study when they were 16 weeks pregnant.
A body mass index (BMI) of more than 25 kg/m2 was defined as overweight or obese, and BMI ranged from 17 to 42 among the women.

The abdominal aorta, the section of the artery extending down to the belly, was scanned in each newborn within seven days of birth to find out the thickness of the internal walls � the intima and media.
Thickening of this main artery is an indication of early atherosclerosis, the disease that leads to the majority of heart attacks and strokes, and is characterised by the development of plaques in the walls of the arteries.

Intima-media thickness ranged from 0.65 to 0.97 mm, and was associated with the mother's weight. The higher a mother's weight, the higher the baby's intima-media thickness, irrespective of how much the baby weighed at birth.
The difference in intima-media thickness between babies of overweight and normal weight moms was 0.06 mm.
"We already know that the children of overweight or obese mothers are more likely to become overweight and obese themselves, which will potentially increase their risk of heart attack and stroke in adulthood," said study co-author, Dr Michael Skilton from the University's Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders.

"To our knowledge, this is the first study demonstrating that being an overweight or obese mother can itself potentially lead to poor health of the blood vessels, which is consistent with higher risk of heart disease and stroke in later life," Skilton said in a statement.
"Our findings suggest that overweight/obesity may have an 'intergenerational' effect. That is, that the children of overweight or obese mums may themselves be at higher risk in adulthood of having heart attacks and strokes, irrespective of whether or not they themselves are obese," Skilton added.
The study was a collaboration between the University's Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, the Royal Women's Hospital, Victoria, Department of Obstetrics and Gynaecology, University of Melbourne and the Baker IDI Heart and Diabetes Institute.

The study was published in the Fetal and Neonatal Edition of Archives of Disease of Childhood.