Gen. Matiullah Khan, police chief of Uruzgan province, said the explosion hit a building with a hotel and restaurant in Tirin Kot, southern Afghanistan.
He warned that several people are seriously wounded. There was no immediate claim of responsibility for the attack.
In a separate incident, three civilians were killed by a roadside bomb in southern Afghanistan's Helmand Province. Omer Zawak, spokesman for the provincial governor, said three other people were wounded in the attack in Marjah District.
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