In its report, the Congressional Research Service (CRS) -- an independent and bi-partisan research wing of US Congress -- said Sindh historically has possessed many of the trappings of a modern nation-state.
"Yet it exists in a circumstance wherein its autonomy (and that of Pakistan's other minority provinces") is significantly restrained by a politically and demographically dominant Punjabi province and ethnicity," said the report.
"Although Sindh has always possessed most of the characteristics required for a viable independent state - and some nationalist sentiments persist to this day - its role as Punjab's conduit to the sea may well be the ultimate reason that successful Sindhi separatism faced long odds," it said.
A copy of the report was released to the media by Congressman Brad Sherman, who is the co-Chair of the small Congressional Caucus on Sindh.
According to the report, Sindh's Mohajirs (Urdu-speaking people who migrated from India during partition) had their own autonomist movement from the mid-1980s until the early 2000s.
This was rooted in that community's loss of preeminence in provincial politics, bureaucracy, and industry, its lack of meaningful representation in the army, and its loss of identity following migration, among other factors.
After the 1970 election elevated a Sindhi to the prime ministership, Mohajir student organisations began efforts to consolidate community identity, and in 1984 the Muttahida Quami Movement (MQM) political party was founded, one with an early "penchant for torture, kidnapping, and murder."
Yet the party remains a major player in the province and has continued to be dominant in Karachi proper. Sindhi-Mohajir frictions remain unresolved, especially given widespread perceptions among Mohajirs that the provincial government is fundamentally unable to serve their needs, the report said.
"Pervasive political, ethnic, and sectarian violence in Karachi has some analysts fearful that nuclear facilities near the city would be subjected to attack by militants.
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