Speaking to US and Japanese troops at the Yokota Air Base outside Tokyo, Pence vowed to continue the "maximum pressure campaign" on North Korea in a bid to force Pyongyang to give up its nuclear missile programme.
Pence's trip to Asia comes amid an apparent thaw on the Korean peninsula, spurred by North Korea's participation in what is being hailed the "peace" Olympics in Pyeongchang in the South.
"Let the world know, from here in Yokota Air Base and beyond, we are ready for any eventuality.
"Let our adversaries know: All options are on the table and the American armed forces and self-defence forces of Japan will be ready to defend our people and our way of life."
Any provocation, including any use of nuclear weapons, would result in a "response that is rapid, overwhelming and effective", he vowed.
He also said Pyongyang would not be allowed to "hijack" the Games in Pyeongchang to distract the world from its military build-up and nuclear weapons programmes.
After addressing the troops, Pence will fly to South Korea to attend Friday's opening ceremony of the Winter Olympics.
He has not directly ruled out holding a meeting with officials from North Korea, which is expected to send Kim Yong Nam, the ceremonial head of state and sister of leader Kim Jong Un.
Nevertheless, according to state news agency KCNA, the North has no intention of meeting US officials during the Games -- but did not rule it out either.
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