"It has become necessary to sell Mr Pistorius's home in the Silver Woods Country Estate in Pretoria in order for him to raise the necessary funds to cover his increasing legal costs," the 27-year-old's lawyer Brian Webber said in a statement.
"This is due to the unexpected extension of the trial beyond the initial three-week period for which it was originally set down."
Pistorius has not returned to the modern, two-storey house since he fatally shot his girlfriend Reeva Steenkamp there on Valentine's Day last year.
Estate agent Ansie Louw, who is handling the sale, told AFP the house will be sold in a closed bid. The bid price was not disclosed, but the property should not go for less than five million rand (USD 460,000, 330,000 euro), she added.
The Paralympic athlete has been paying his own legal fees since the shooting incident, according to Webber's statement.
The costs -- reportedly as high as USD 9,000 (6,700 euros) a day -- are said to include at least three full-time lawyers in court, ballistics and forensics experts as well as an American crime scene reconstruction company.
Prosecutors have charged the double-amputee sprinter with intentionally killing 29-year-old Steenkamp after an argument, and are expected to wrap up their case early next week.
Pistorius insists he fired four shots through a locked toilet door after mistaking the model for an intruder.
The authorities turned the runner's home in the gated community back over to him over a year ago and he had planned to keep it sealed until the trial finished.
"He has been forced to revisit this decision," according to Webber, who said the statement was meant to preempt media speculation about the sale.